ISOrTT Registry References

Selected References on Clinical Transplant Tolerance (Chronological order):


  • 1. Reyes J, Zeevi A, Ramos H, Tzakis A, Todo S, Demetris AJ et al. Frequent achievement of a drug-free state after orthotopic liver transplantation. Transplantation proceedings 1993;25(6):3315-3319.
  • 2. Tzakis AG, Reyes J, Zeevi A, Ramos H, Nour B, Reinsmoen N et al. Early tolerance in pediatric liver allograft recipients. Journal of pediatric surgery 1994;29(6):754-756.
  • 3. Mazariegos GV, Ramos H, Shapiro R, Zeevi A, Fung JJ, Starzl TE. Weaning of immunosuppression in long-term recipients of living related renal transplants: a preliminary study. Transplantation proceedings 1995;27(1):207-209.
  • 4. Ramos HC, Reyes J, Abu-Elmagd K, Zeevi A, Reinsmoen N, Tzakis A et al. Weaning of immunosuppression in long-term liver transplant recipients. Transplantation 1995;59(2):212-217.
  • 5. Mazariegos GV, Reyes J, Marino IR, Demetris AJ, Flynn B, Irish W et al. Weaning of immunosuppression in liver transplant recipients. Transplantation 1997;63(2):243-249.
  • 6. Varela-Fascinetto G, Treacy SJ, Vacanti JP. Approaching operational tolerance in long-term pediatric liver transplant recipients receiving minimal immunosuppression. Transplantation proceedings 1997;29(1-2):449-451.
  • 7. Devlin J, Doherty D, Thomson L, Wong T, Donaldson P, Portmann B et al. Defining the outcome of immunosuppression withdrawal after liver transplantation. Hepatology (Baltimore, Md 1998;27(4):926-933.
  • 8. Wong T, Nouri-Aria KT, Devlin J, Portmann B, Williams R. Tolerance and latent cellular rejection in long-term liver transplant recipients. Hepatology (Baltimore, Md 1998;28(2):443-449.
  • 9. Takatsuki M, Uemoto S, Inomata Y, Egawa H, Kiuchi T, Fujita S et al. Weaning of immunosuppression in living donor liver transplant recipients. Transplantation 2001;72(3):449-454.
  • 10. Takatsuki M, Uemoto S, Inomata Y, Sakamoto S, Hayashi M, Ueda M et al. Analysis of alloreactivity and intragraft cytokine profiles in living donor liver transplant recipients with graft acceptance. Transplant immunology 2001;8(4):279-286.
  • 11. Thomson AW, Mazariegos GV, Reyes J, Donnenberg VS, Donnenberg AD, Bentlejewski C et al. Monitoring the patient off immunosuppression. Conceptual framework for a proposed tolerance assay study in liver transplant recipients. Transplantation 2001;72(8 Suppl):S13-22.
  • 12. Mazariegos GV, Reyes J, Webber SA, Thomson AW, Ostrowski L, Abmed M et al. Cytokine gene polymorphisms in children successfully withdrawn from immunosuppression after liver transplantation. Transplantation 2002;73(8):1342-1345.
  • 13. McCaughan GW. Withdrawal of immunosuppression in liver transplant recipients: is this as good as it gets? Liver Transpl 2002;8(4):408-410.
  • 14. Oike F, Yokoi A, Nishimura E, Ogura Y, Fujimoto Y, Kasahara M et al. Complete withdrawal of immunosuppression in living donor liver transplantation. Transplantation proceedings 2002;34(5):1521.
  • 15. Hernandez-Fuentes MP, Warrens AN, Lechler RI. Immunologic monitoring. Immunological reviews 2003;196:247-264.
  • 16. Mazariegos GV, Zahorchak AF, Reyes J, Ostrowski L, Flynn B, Zeevi A et al. Dendritic cell subset ratio in peripheral blood correlates with successful withdrawal of immunosuppression in liver transplant patients. Am J Transplant 2003;3(6):689-696.
  • 17. Starzl TE, Murase N, Abu-Elmagd K, Gray EA, Shapiro R, Eghtesad B et al. Tolerogenic immunosuppression for organ transplantation. Lancet 2003;361(9368):1502-1510.
  • 18. Hurwitz M, Desai DM, Cox KL, Berquist WE, Esquivel CO, Millan MT. Complete immunosuppressive withdrawal as a uniform approach to post-transplant lymphoproliferative disease in pediatric liver transplantation. Pediatric transplantation 2004;8(3):267-272.
  • 19. Li Y, Koshiba T, Yoshizawa A, Yonekawa Y, Masuda K, Ito A et al. Analyses of peripheral blood mononuclear cells in operational tolerance after pediatric living donor liver transplantation. Am J Transplant 2004;4(12):2118-2125.
  • 20. Mazariegos GV. Withdrawal of immunosuppression in liver transplantation: lessons learned from PTLD. Pediatric transplantation 2004;8(3):210-213.
  • 21. De Ruvo N, Cucchetti A, Lauro A, Masetti M, Di Benedetto F, Cautero N et al. Minimization of immunosuppression with thymoglobuline pre-treatment and HCV recurrence in liver transplantation. Clinical transplantation 2005;19(2):255-258.
  • 22. Derks RA, Burlingham WJ. In vitro parameters of donor-antigen-specific tolerance. Current opinion in immunology 2005;17(5):560-564.
  • 23. Eason JD, Cohen AJ, Nair S, Alcantera T, Loss GE. Tolerance: is it worth the risk? Transplantation 2005;79(9):1157-1159.
  • 24. Girlanda R, Rela M, Williams R, O'Grady JG, Heaton ND. Long-term outcome of immunosuppression withdrawal after liver transplantation. Transplantation proceedings 2005;37(4):1708-1709.
  • 25. Knechtle SJ. Development of tolerogenic strategies in the clinic. Philosophical transactions of the Royal Society of London 2005;360(1461):1739-1746.
  • 26. Mazariegos GV, Zahorchak AF, Reyes J, Chapman H, Zeevi A, Thomson AW. Dendritic cell subset ratio in tolerant, weaning and non-tolerant liver recipients is not affected by extent of immunosuppression. Am J Transplant 2005;5(2):314-322.
  • 27. Reding R, Gras J, Bourdeaux C, Wieers G, Truong QD, Latinne D et al. Stepwise minimization of the immunosuppressive therapy in pediatric liver transplantation. A conceptual approach towards operational tolerance. Acta gastro-enterologica Belgica 2005;68(3):320-322.
  • 28. Tryphonopoulos P, Tzakis AG, Weppler D, Garcia-Morales R, Kato T, Madariaga JR et al. The role of donor bone marrow infusions in withdrawal of immunosuppression in adult liver allotransplantation. Am J Transplant 2005;5(3):608-613.
  • 29. Yoshizawa A, Ito A, Li Y, Koshiba T, Sakaguchi S, Wood KJ et al. The roles of CD25+CD4+ regulatory T cells in operational tolerance after living donor liver transplantation. Transplantation proceedings 2005;37(1):37-39.
  • 30. Lerut J, Sanchez-Fueyo A. An appraisal of tolerance in liver transplantation. Am J Transplant 2006;6(8):1774-1780.
  • 31. Reding R, Gras J, Truong DQ, Wieers G, Latinne D. The immunological monitoring of alloreactive responses in liver transplant recipients: a review. Liver Transpl 2006;12(3):373-383.
  • 32. Roussey-Kesler G, Giral M, Moreau A, Subra JF, Legendre C, Noel C et al. Clinical operational tolerance after kidney transplantation. Am J Transplant 2006;6(4):736-746.
  • 33. Starzl TE, Lakkis FG. The unfinished legacy of liver transplantation: emphasis on immunology. Hepatology (Baltimore, Md 2006;43(2 Suppl 1):S151-163.
  • 34. Tisone G, Orlando G, Cardillo A, Palmieri G, Manzia TM, Baiocchi L et al. Complete weaning off immunosuppression in HCV liver transplant recipients is feasible and favourably impacts on the progression of disease recurrence. Journal of hepatology 2006;44(4):702-709.
  • 35. Ashton-Chess J, Giral M, Brouard S, Soulillou JP. Spontaneous operational tolerance after immunosuppressive drug withdrawal in clinical renal allotransplantation. Transplantation 2007;84(10):1215-1219.
  • 36. Kawasaki M, Iwasaki M, Koshiba T, Fujino M, Hara Y, Kitazawa Y et al. Gene expression profile analysis of the peripheral blood mononuclear cells from tolerant living-donor liver transplant recipients. International surgery 2007;92(5):276-286.
  • 37. Khera N, Janosky J, Zeevi A, Mazariegos G, Marcos A, Sindhi R. Persistent donor-specific alloreactivity may portend delayed liver rejection during drug minimization in children. Front Biosci 2007;12:660-663.
  • 38. Koshiba T, Li Y, Takemura M, Wu Y, Sakaguchi S, Minato N et al. Clinical, immunological, and pathological aspects of operational tolerance after pediatric living-donor liver transplantation. Transplant immunology 2007;17(2):94-97.
  • 39. Martinez-Llordella M, Puig-Pey I, Orlando G, Ramoni M, Tisone G, Rimola A et al. Multiparameter immune profiling of operational tolerance in liver transplantation. Am J Transplant 2007;7(2):309-319.
  • 40. Mazariegos GV, Sindhi R, Thomson AW, Marcos A. Clinical tolerance following liver transplantation: long term results and future prospects. Transplant immunology 2007;17(2):114-119.
  • 41. Tisone G, Orlando G, Angelico M. Operational tolerance in clinical liver transplantation: emerging developments. Transplant immunology 2007;17(2):108-113.
  • 42. Wieers G, Gras J, Bourdeaux C, Truong DQ, Latinne D, Reding R. Monitoring tolerance after human liver transplantation. Transplant immunology 2007;17(2):83-93.
  • 43. Akalin E. Immunosuppression minimization protocols: how should they be monitored? Nature clinical practice 2008;4(9):484-485.
  • 44. Martinez-Llordella M, Lozano JJ, Puig-Pey I, Orlando G, Tisone G, Lerut J et al. Using transcriptional profiling to develop a diagnostic test of operational tolerance in liver transplant recipients. The Journal of clinical investigation 2008;118(8):2845-2857.
  • 45. Sindhi R, Higgs BW, Weeks DE, Ashokkumar C, Jaffe R, Kim C et al. Genetic variants in major histocompatibility complex-linked genes associate with pediatric liver transplant rejection. Gastroenterology 2008;135(3):830-839, 839 831-810.
  • 46. Starzl TE. Immunosuppressive therapy and tolerance of organ allografts. The New England journal of medicine 2008;358(4):407-411.
  • 47. Tokita D, Mazariegos GV, Zahorchak AF, Chien N, Abe M, Raimondi G et al. High PD-L1/CD86 ratio on plasmacytoid dendritic cells correlates with elevated T-regulatory cells in liver transplant tolerance. Transplantation 2008;85(3):369-377.
  • 48. Toyokawa H, Nakao A, Bailey RJ, Nalesnik MA, Kaizu T, Lemoine JL et al. Relative contribution of direct and indirect allorecognition in developing tolerance after liver transplantation. Liver Transpl 2008;14(3):346-357.